Aptitude

Science & Technology

To measure or manipulate any biomolecule among sea of non-target molecules requires exquisite molecular recognition

the issues with antibodies

Antibody-based products are the conventional solution for biomarker recognition. Antibodies, however, possess fundamental limitations that have created a bottleneck in market growth.

  • Limited Dx & Rx applications due to insufficient chemical modifiability and target range
  • Higher cost due to biological system, challenging quality control and refrigeration requirements
  • Slow development cycles due to prolonged antibody discovery (4-6 months)
  • Low performance due to fundamental limitations in affinity and specificity
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the Aptitude solution

Aptitude provides synthetic affinity molecules - a new generation of aptamers with major advantages.

  • Expanded target range including nonimmunogenic proteins, peptides, toxins, glycans, drugs, metabolites, small epitopes
  • Fully synthetic, highly stable renewable molecules
  • Simple and site-specific conjugation and modification
  • Rapid development and production completed in weeks
  • Unprecedented affinity and specificity
  • Differentiate homologous targets or conformational changes
  • Bispecificity
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the Aptitude revolution

Aptitude is making aptamers truly useful for the first time.

  • Integrated suite of proprietary technologies that unlock the full potential of aptamers
  • Proprietary aptamers with demonstrated unprecedented performance, throughput, and application capability
  • Technology validated in over 20 high impact journal publications and highlights
  • Commercial impact validated by repeated success in major industry partnerships
aptitude_product_group

 

1st Generation Traditional Discovery

2nd Generation Non-natural Nucleotides

3rd Generation Aptitude Discovery

Success rate

Performance

Speed

Cost

Aptamer pairs

Impure/
surface targets

Specificity tailoring

the Aptitude impact

Immense benefits for Life Science and Medicine

  • New applications and assays for new and challenging biomarkers
  • More sensitive and specific assays
  • Solve cross-reactivity limits in multiplex assays
  • Minimized batch-to-batch variation and superior quantification
  • No cold storage and expanded shelf life
  • Less hands on time and manual steps
  • Suitable for any assay format